American Journal of Histology and Cytology


Genetic Factors and Clinical Characteristics of Early Alzheimer

Review Article of American Journal of Histology and Cytology Genetic Factors and Clinical Characteristics of Early Alzheimer Soares, T. A. B ¹; Cursino, G. T ²; Donato H. M. G ³; Luis J. M. S 4; Ferreira K. M. L. M 5; Souza M. B. R 6. 1,2,3,4,5 Medical student - UNICAP; 6Professor/researcher at the Department of Biological Sciences and Health - UNICAP; Introduction: Alzheimer’s disease (AD) is an irreversible and progressive neurodegenerative disorder of insidious onset that causes loss of memory and various cognitive disorders. Early AD represents 5% of all cases of this pathology, demonstrating a family recurrence that initially presents a relative preservation of cognition. Its development is directly related to mutated genes that cause changes in the proteins encoded by them. Objectives: To describe the genetic factors and clinical characteristics of early Alzheimer’s disease. Methodology: Articles published between 2000 and 2010 were pre-selected through the PubMed and SciELO databases, using the descriptor: alzheimer. A total of 73 texts were analyzed, of which 54 were selected after the study of titles and abstracts. Considering inclusion and exclusion criteria, only 13 were included in the review because they refer to Early AD theme in the descriptors and abstracts. Results and Discussion: The genetic factor is considered crucial in the disease. The cases behave according to an autosomal dominant monogenic hereditary pattern in heterozygous individuals for the mutated gene (Aa), since the dominant gene is rare in the population. Studies suggest that the reduction in the level or activity of APP fragments plays a critical role in cognitive dysfunction, including the genes of PSEN1 and PSEN2 as well as responsible for this involvement. Early signs tend to be ignored because of their early character, presenting characteristics of behavioral changes, personality or depressive symptoms, with relative cognitive preservation. Conclusion: Early ...

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1.Santos, G. A.; Ramos, L. V. S.; Santana, J. F.; Lima, L. F. A; França, L. C.; Maia, C. S. Differential Diagnosis for Incisive Channel Cysts.American Journal of Histology and Cytology, 2018, 1:3. DOI: 10.28933/ajohc-2018-05-1803 
2.Soares, T. A. B; Cursino, G. T; Donato H. M. G; Luis J. M. S; Ferreira K. M. L. M; Souza M. B. R. Genetic Factors and Clinical Characteristics of Early Alzheimer. American Journal of Histology and Cytology, 2018, 1:2. DOI: 10.28933/ajohc-2018-05-1802 

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American Journal of Histology and Cytology is a peer reviewed open access journal publishing research manuscripts, review articles, editorials, letters to the editor in Histology and Cytology (Indexing information).

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American Journal of Histology and Cytology

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