Intermittent fasting (IF) is currently one of the world’s most popular health and fitness trends. Several IF patterns have been studied. Not all were shown to be equally effective. Also, each person’s experience of intermittent fasting is individual, and different styles will suit different people. The potential health benefit list of IF is long: accelerated weight loss, reduced inflammation, lower cholesterol, longer lifespan, blood sugar stabilization, and prevention of type 2 diabetes. Emerging research suggests IF may also lead to a healthier brain, longer life, and even aid cancer treatment. Placing time restrictions on feeding has been shown to have broad systemic effects and trigger similar biological pathways as caloric restriction. One key mechanism responsible for many of these beneficial effects appears to be “flipping” of the metabolic switch. The metabolic switch typically occurs in the third phase of fasting when glycogen stores in hepatocytes are depleted and accelerated adipose tissue lipolysis produces increased fatty acids and glycerol. Just changing the timing of meals, by eating earlier in the day and extending the overnight fast, significantly benefited metabolism even in people who didn’t lose a single pound.
The skin aging process, which is prompted by environmental variables, is named untimely or extrinsic skin aging process and can be recognized from the sequentially (intrinsic) skin aging process by trademark skin aging signs. Albeit human skin goes about as a biological shield against pro-oxidative chemicals and physical air pollutants, prolonged or tedious presentation to abnormal amounts of these pollutants may have profound negative impacts on the skin. Sexual orientation contrasts in toxicity have been accounted for some substances. Youngsters are known to be increasingly defenseless against the antagonistic health impacts of air pollution. Environmental pollution by traffic is additionally connected with the event of indications of extrinsic skin aging. Heavy metals, for example, cadmium, lead and mercury are regular air pollutants that posture health hazards because of bioaccumulation. Ozone in the stratosphere has protective impacts by sifting solar UVR; be that as it may, in the troposphere ozone has toxic implications for skin. Because of scarcity of logical proof, there are no settled rules as of now accessible for protecting the skin against air pollution. Beside lessening presentation, potential protection techniques should concentrate on fixing the skin barrier, renewing antioxidant save, and diminishing inflammation brought about via air pollutants.
Liver cirrhosis with high IgG4 in a patient with, diabetes mellitus, ulcerative colitis with papillary thyroid cancer, is it all related ? which one to blame& is it time to raise awareness about IGG4 and hepatobiliary diseases
Back ground: There is possible etiological relation between high IgG4 in a patient with liver cirrhosis, ulcerative colitis, diabetes mellitus , prostatitis ,venous thrombosis and thyroid cancers and the use of immunosuppressive & biologic agents. Method: a study of patient with multiple organ involvement with persistently elevated IgG4. A 56 years old male with persistently elevated IgG4 over 2.5 times normal level, diabetic on insulin, ulcerative colitis on azathioprin & adalimumab developed deep skin pigmentation and liver enzymes elevation with portal hypertension and liver cirrhosis, azathioprine & adalimumab were stopped and golimumab started, after 3 infusions of golimumab papillary thyroid cancer developed .Total thyroidectomy followed by radio iodine after which severe sialo adenitis developed which responded to steroids. His ulcerative colitis was treated with vedolizumab with good response. liver cirrhosis progressed with bleeding varices and portal vein thrombosis with factor Leiden V mutation. Results and conclusions: High IgG4 can be related to many organs including pancreas,liver,thyroid ,small and large bowel,parotid glands ,in this patients all these were affected resulting in colitis,diabetes,liver cirrhosis and thyroid cancer and sialo adenitis. Awareness is needed on the associations with high IgG4. Conclusion: A patient with elevated IgG4 , liver cirrhosis , diabetes mellitus, ulcerative colitis developed skin pigmentation, and papillary thyroid cancer associated with persistently elevated IgG4.
This article covers the epidemiology, pathophysiology/complications and management of diabetic gastroparesis (DGP), and more broadly diabetic gastroenteropathy, which encompasses all the gastrointestinal manifestations of diabetes mellitus (DM). Hyperglycemia, autonomic neuropathy, and enteric neuromuscular inflammation and injury are implicated in the pathogenesis of delayed gastric emptying (GE). Initial options include dietary modifications, supplemental oral nutrition, and antiemetic and prokinetic medications. Patients with more severe symptoms may require a venting gastrostomy or jejunostomy and/or gastric electrical stimulation (GES). To date, few population-based studies have estimated the true prevalence and incidence of gastroparesis. Nonetheless, its prevalence appears to be rising, as does its incidence among minority populations, documented via hospitalizations, which can impose significant economic burdens on patients.
ANALYSIS OF BOKO HARAM INSURGENCY ACTIVITES IN NORTH EASTERN NIGERIA: A GEOGRAPHICAL INFORMATION SYSTEM APPROACH
Over the years, Nigeria as a Nation has been witnessing serious unrest characterized by the ethnic, political, farmer’s-herder’s conflict and activities of the insurgency. The north eastern geo-political zone of Nigeria was not left out of the activities. The activities of the Boko Haram insurgents has led to over ten thousand people losing their life and properties making many homeless. The paper is aimed at providing a comprehensive data and show the spatial distribution of activities of Boko Haram insurgency in Adamawa, Borno and Yobe States between 2009 and 2017. The paper utilizes secondary data from Armed Conflict Data (ACLED), printed materials, newspaper records, journals, and security agencies records. The method of analysis utilized in the study is Geographical Information System (GIS) approach using ArcGIS software and graphs to indicate the activities of the insurgency. The finding of the research shows that Borno State has the highest occurrence of insurgency and Yobe State recorded the lowest. The study concludes that the activities of the insurgents are more at the northern part and along the international boundaries.
Many fungi including Penicillium and Aspergillus species produces patulin in the contaminated foods. Patulin is a heterocyclic unsaturated lactone that reacts with SH group of biological molecules causing harmful effects in human and animal tissues. Hence, the present investigation was designed to evaluate the possible teratogenic effect of patulin (0.002mg/kg b. wt) which was examined through the induction of dominant lethal gene and the alteration in number of live births in the female rats . Results and Conclusion: patulin is a dangerous teratogen in rats. This was confirmed by the significant increase in the percentage of maternal and embryo toxicities.
Purpose: The study investigated the librarians’ use of Social Media for library service delivery in the university libraries in Nigeria. Methodology: The research adopted the descriptive design survey. The sample size of this research study comprised of (40) forty librarians from Federal University Otuoke and Niger Delta University, wiberforce iland, both in Bayelsa State. A well self-structured questionnaire was used to collect data. Findings: The Friday showed that social media tools were used among Librarians for sharing posting and disseminating of inaugural lecture, conference via You-Tube for other academic improvement. The finding revealed that Facebook was most consulted social media tool among librarian in the variously libraries. Closely followed were YouTube, Instant Message and Twitter respectively. The finding indicated that lack of awareness and the unreliable power supply were the two major challenges librarians faced while using social media to provide services in the university library. Closely followed was the low bandwidth. The study revealed that overdue notices, reference service, marketing and promotion of information products, displayed of new arrival of collection were some of the major services rendered by librarian in the university librarian in Nigeria. Originality: The result of this research will be beneficial to the librarians and the teaming users in general, especially in the area of awareness of social media tools, service delivery via social media tools and overcoming challenges facing librarian while using several media in providing services.
LIBRARIANS’ COMPETENCIES AND STUDENTS SATISFACTION WITH INFORMATION SERVICES IN UNIVERSITY OF UYO LIBRARY
The study investigates librarians’ competencies and students’ satisfaction with information services in University of Uyo Library. Three objectives, three research questions and three hypotheses were formulated for the study. The study covered University of Uyo library. Ex-post facto research design was used for the study. The population of the study comprised 1,855 registered users in the University of Uyo Library during the 2016/2017 academic session. The sample size of the study was 185 respondents using 10% of the total population. Simple random sampling techniques were used to select sample size for the study. The data collected were analyzed using mean and standard deviation for all the three research questions; while t-test were used for test the three null hypotheses. The finding of the study shows that there is a significant influence of librarians’ knowledge of information resources on students’ satisfaction with information services. There is a significant influence of librarians’ technical skills on students’ satisfaction with information services. There is a significant influence of librarians’ interpersonal skills on students’ satisfaction with information services. The study was recommended that the Librarians should be well grounded in the knowledge of information resources that exist not only in academic library but other libraries and information centres in order to effectively serve the library community and create effective referral. Librarians as a matter of urgency should strive to develop themselves in information literacy and information technology as these are important in the present knowledge economy in order to remain relevant as information service provider and this can be gotten through continuing education, workshops, seminars and conferences. Librarians should always wear a friendly outlook in the discharge of their duties in order to create a positive environment for collaboration that will engender maximum use of the library resources to the satisfaction of the information need…
This study analysed the long run relationship between economic growth, foreign direct investment, foreign trade, inflation, exchange rate, imports and exports for the period of 1980-2011 using annual time series analysis. It examined the dependency of economic growth on foreign trade, exchange rate, inflation and foreign direct investment. Trade openness, foreign direct investment and inflation are found stationary at level while imports, exports, exchange rate and economic growth are stationary at first difference. All the variables have long run relationship according to cointegration results. DOLS results showed that imports and exports have significant positive relationship, inflation and foreign trade have significant negative impact, and exchange rate and foreign direct investment have insignificant positive influence on economic growth. The negative impact of foreign trade can be overcome by producing import substitutes and creating conditions for trade surplus. Other policy reforms are also required to enhance the economic growth.
At present, power grid construction is playing a more and more important role in development of China power sector because of maldistribution of electric energy. This passage is based on three steps in the electrified wire netting construction process: power transformation, transmission, distribution. By summing up the feature of them, some conclusions about influence factors of power grid operating costs are required. After that, this paper analyzes negative influence of high costs. At last, keeping a reasonable control on single cost is put forward to make controlling total costs strongly possible.