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  • Discussion on the Design of Cultural Commercial Complex—Taking a design of a cultural and commercial complex next to a university in Yichang as an example

    As the social economy develops faster and faster, the functions of commercial complex buildings become more and more diverse. It is not only a place to shop, but also a place to gather a place of popularity. Therefore, in addition to providing a shopping place, it also has the function of providing a gathering place for leisure and entertainment, and can become a landmark building of a city. Therefore, we hope that through the analysis of the design features of this work, a complete and detailed architectural design idea for the design of such commercial complexes can be proposed.

  • Elderly architectural design based on humanized concept—Take the design of a nursing home in Yichang, hubei province as an example

    This nursing home architectural design is based on a human perspective.The article elaborates on the corresponding design of the building to meet the psychological needs and living habits of the elderly.This is to help to explore how to design a qualified nursing home that meets the physical and mental needs of the elderly in today’s social situation.

  • On the climate adaptability design of hot summer and cold winter regions-Taking the design works of Huzhai Sanjia Kindergarten in Lancao County as an example

    This article takes the example of the 8th China Dream Township-Product Creative Design Competition in 2019, the three-parent kindergarten in Huzhai Village, Lankao County, Kaifeng City as an example. According to the local climate characteristics, architectural forms, building materials and other aspects combined with ecological design means to create a suitable summer. Green kindergartens with climatic conditions in hot winter cold regions. The design mainly starts with the contradiction between kindergarten use and regional climate. Through the optimization design of environment design, layout optimization, lighting and ventilation optimization and material adoption, an ecological design method is proposed for rural kindergartens in hot summer and cold winter regions.

  • Regional cultural expression of cultural architecture—Take the design works of Yichang History and Culture Theme Exhibition Hall as an example

    Cultural buildings have distinct regional characteristics. How to make them have regional characteristics is an important point to judge the success or failure of a cultural building design. Take Yichang City’s cultural architecture design as an example to explore how regional cultural characteristics are reflected in the architecture. From the aspects of humanities and natural environment, we provide an in-depth analysis of the cultural design of local characteristics, and discuss the specific application of different factors in the design of stylistic architecture.

  • Hydroethanolic extract of Theobroma cacao beans is non toxic and attenuates oxydative stress induced by Naphtalene in Wistar rats

    Background: Oxidative stress is a situation where the cell no longer controls the excessive presence of toxic oxygen radicals. Many human diseases have a strong relationship with oxidative stress due to an imbalance between antioxidants and pro-oxidants. The objective of this study is to evaluate the in vivo antioxidant capacity of Theobroma cacao (T.cacao) beans extract and its acute toxicity. Methods: T. cacao beans were collected in the Obala locality (Center Cameroon) and then subjected to hydroethanolic extraction (70:30) at pH 3. The in vivo oxidative stress induction was done using naphthalene at 110 mg / kg and different doses of extracts (50 mg / kg, 100 mg / kg, and 200 mg / kg) were orally administered to rats. Some oxidative stress parameters helped to evaluate the antioxidant potential of the extract (superoxide dismutase (SOD), reduced glutathione (GSH) and malondialdehyde (MDA)). In addition, the acute toxicity of T. cacao was evaluated by the methods recommended by the ODCE. Test groups received respectively the extract at different doses (5000 mg / kg and 2000 mg / kg) against 10% of DMSO and distilled water as neutral controls. Hepatic function was assessed using transaminase assays (ASAT, ALAT), proteins and histological sections. Also the blood count allowed to explore the haematological function. Results: The administration of different doses of extracts or vitamin C as standard significantly increased GSH levels as well as antioxidant enzymes (SOD, CAT) and a significant decrease in MDA in studied organs and serum of animals compared to pro-oxidant control. ALAT and ASAT activities did not significantly vary in rats compared to neutral controls. No deaths and hepatic injuries were observed at different doses of the extracts. Conclusion: The extract of T. cacao beans possess in vivo antioxidant capacities capable of protecting tissues against oxidative stress and toxicity in…

  • Anti-bacterial Activity of Aqueous and Methanolic Root Extracts of Medicinal Plant Heteropogon contortus

    Synthetic drugs available for the treatment of chronic and infectious diseases are very expensive and some of them have become less effective due to the emergence of antibiotic resistance. Researchers are now focused on natural sources including plants and plant parts for the development of novel therapeutic agents. Therefore, this study evaluated in vitro anti-bacterial activity and phytochemical composition of aqueous and methanolic root extracts of Sri Lankan medicinal plant Heteropogon contortus against clinically significant pathogens, Escherichia coli (ATCC 25922) and Staphylococcus aureus (ATCC 25923). Agar well diffusion method and standard chemical tests were performed to evaluate anti-bacterial effect and phytochemical profile of the root extracts, respectively. The results revealed that each crude root extract exhibited anti-bacterial activity against both E. coli and S. aureus. The largest zones of inhibition against both E. coli and S. aureus were detected from the methanolic root extract at a concentration of 200 mg/mL and this is a novel finding. Phytochemical analysis of roots revealed the presence of bioactive constituents that account for the anti-bacterial potential, such as alkaloids, phenols and flavonoids. Thereby, root of H. contortus is a reliable source to develop potent, cheap and natural anti-bacterial agents. Future research focusing on high concentrations of different root extracts is recommended to further understand the anti-bacterial capability of H. contortus.

  • The Role of Maternal Stress, Cortisol and Interleukin-12 in Cases of Missed Abortion in the First Trimester of Pregnancy in Saudi Women

    Missed abortion in early pregnancy is a common gynecological condition, and the incidence has been increasing presenting itself as a public health problem. This study aimed to examine stress, cortisol concentration, and altered IL-12 levels in women who experienced missed abortions. Women with missed abortions (n = 40) were matched with control women of the same age in the same stage of pregnancy (n = 30). Participants filled out a survey about common stress factors. Venous blood samples were taken from the patients at 7:00 a.m. ELISA detected IL-12 concentrations, and serum cortisol was measured by electrochemiluminescence immunoassay. Women with missed abortions reported significantly more common stressors, and their serum cortisol and IL-12 concentrations were significantly higher than those of the women with healthy pregnancies (all P< 0.05). Receiver operating characteristic (ROC) analysis was used to assess the power of the studied parameters to predict women at risk for missed abortion. IL-12 performed the best in predicting women with missed abortions as it had the highest area under the curve (AUC), followed by cortisol. Stress and changes in the immune system may play a role in the etiology of missed abortion in Saudi women in early pregnancy.

  • The schedule of World Cup and its impact on the team

    This paper discusses the organization of the World Cup competition, in which through the establishment of a number of scheduling model, the use of analytic hierarchy process and stochastic simulation and other methods to solve this problem and obtain a more reasonable arrangement of the competition. For the arrangement of the Order of the game, first of all, the existing competition is studied. On the premise of the increase in the number of teams and the previous arrangement of the group points, it is considered from the appropriateness of the field, whether the schedule is wonderful, whether the arrangement is simple and whether the ranking is reasonable. 3 new competition competitions are proposed for the improvement of the original competition. Then, the analytic hierarchy process is used to compare and analyze the 3 new competition methods, and the optimal competition method is selected. Finally, under the previously established game, FIFA’s integral algorithm formula is used to analyze and calculate the impact of the results produced under the competition on FIFA rankings. In the application of formula calculation, the stochastic factor is introduced, and the results are simulated by computer, which can get the approximate upward trend of the team in different ranking intervals.

  • Study on the Impact of Climate Change on Regional Instability

    In this paper we will discuss the problem on how the regional instability of a country can be affected by the climate change. Based on the data collected about the national vulnerabilities, we select fifteen indicators by the principal component analysis. A new three-level indicator system is then established to assess the country’s vulnerability. To obtain and optimize the weight for each indicator used at different levels, the Analytic Hierarchy Process (AHP) and Gray Relational Analysis (GRA) are used. Based on this work, a measurement system including the climate, economic, security, politics and human development is set up to measure the vulnerability of the country.

  • Public Health aspects of Cesarean section including overuse and underuse of the procedure

    Caesarean section (CS) is lifesaving medical procedure that is able to avert both maternal and neonatal mortality. However, across the globe an estimated 3.2 million necessary CSs do not happen in low income countries and an estimate of 6.2 million unnecessary CSs happen in middle and high income countries. The overuse and underuse of this procedure driven by both the supply-side (such as resources within the health system, healthcare policy and strategies, health financing systems and perceptions of the healthcare professional) and demand-side (such as socio-economic status, population preference and perceptions and trust in health system) determinants. There are stark inequities in CS rates between and within regions and countries. Many regions across the globe (Eastern Asia, Northern Europe, Central America, Southern America, Northern America and Oceania) have over double recommended optimal rates, whereas several African regions (Eastern, Middle and Western) have dangerously low rates. Both of these have detrimental impacts on maternal and neonatal outcomes. There is a need now for health policy and decision makers at both national and facility level to try and optimize the CS rates through facilitating strategies that promote positive human relations and encourage standardized evidence based care.