Review Article of International Journal of Bioscience and Medicine
Environmental Enrichment in the ISS Rodent Habitat Hardware System
Sophie Orr1, Rhonda Weigand2, Tanner Adams2, Raycho Raychev3 & Yuri Griko4
1 University of North Dakota, Grand Forks, ND, USA
2 Redlands Community College, El Reno, OK, USA
3 Space Challenges Program, EnduroSat Inc. Sofia, Bulgaria
4 Division of Space Biosciences, NASA Ames Research Center, Moffett Field, CA, USA
Responses of animals exposed to microgravity during in-space experiments were observed via available video recording stored in the NASA Ames Life Sciences Data Archive. These documented observations of animal behavior, as well as the range and level of activities during spaceflight, clearly demonstrate that weightlessness conditions and the extreme novelty of the surroundings exert damaging psychological stresses on the inhabitants. In response to a recognized need for in-flight animals to improve their wellbeing we propose to reduce such stresses by shaping and interrelating structures and surroundings to satisfying vital physiological needs of inhabitants. A Rodent Habitat Hardware System (RHHS) based housing facility incorporating a tubing network system, to maintain and monitor rodent health environment with advanced accessories has been proposed. Placing mice in a tubing-configured environment creates more natural space-restricted nesting environment for rodents, thereby facilitating a more comfortable transition to living in microgravity. A sectional tubing structure of the RHHS environment will be more beneficial under microgravity conditions than the provision of a larger space area that is currently utilized.
The new tubing configuration was found suitable for further incorporation of innovative monitoring technology and accessories in the animal holding habitat unit which allow to monitor in real-time monitoring of valuable health related biological parameters under weightlessness environment of spaceflight.
Keywords: Environmental Enrichment, ISS Rodent Habitat Hardware System
How to cite this article:
Sophie Orr et al.,. Environmental Enrichment in the ISS Rodent Habitat Hardware System. International Journal of Bioscience and Medicine, 2017; 1:6. DOI: 10.28933/ijbm-2017-10-2601
2 Baumans V (2005) Environmental Enrichment for Laboratory Rodents and Rabbits: Requirements of Rodents, Rabbits, and Research. ILAR Journal 46: 162-170
3 Baumans V, Van Loo PLP (2013) How to improve housing conditions of laboratory animals: The possibilities of environmental refinement. The Veterinary Journal 195: 24-32
4 Borkowski GW, Lane, P (1995) Laboratory Animals in Space Life Sciences Research. Animal Welfare Information Center newsletter v.6:no.2-4
5 Burkholder T, Foltz C, Karlsson E, Linton CG, Smith JM (2012) Health Evaluation of Experimental Laboratory Mice. Current protocols in mouse biology 2: 145-165
6 Cancedda R, Liu Y, Ruggiu A, Tavella S, Biticchi R, Santucci D, Schwartz S, Ciparelli P, Falcetti G, Tenconi C, Cotronei V, Pignataro S (2012) The Mice Drawer System (MDS) Experiment and the Space Endurance Record-Breaking Mice. PLoS ONE 7: e32243
7 Centers for Disease Control and Prevention and U.S. Department of Housing and Urban Development (2006) Healthy Housing Reference Manual. Atlanta: United States Department of Health and Human Services.
8 Chu V, Otero JM, Lopez O, Morgan JP, Amende I, Hampton TG (2001) Method for non-invasively recording electrocardiograms in conscious mice. BMC Physiology 1: 6-6.
9 Crawley, J. (2007). What’s Wrong With My Mouse?: Behavioral Phenotyping of Transgenic and Knockout Mice, 2nd Edn., New Jersey, NY: Wiley-Interscience.
10 About the International Space Station. In NASA – Ames Agency Alignment, Colen J (ed) NASA.gov: NASA
11 Committee for the Update of the Guide for the Care and Use of Laboratory Animals, Institute for Laboratory Animal Research, Division on Earth and Life Studies, National Research
12 Council (2011) Guide for the Care and Use of Laboratory Animals. 8th ed. Washington, DC: The National Academies Press. Chapter 3, Environment, Housing, and Management; p. 41-104.
13 Ennaceur A (2014) Tests of unconditioned anxiety — Pitfalls and disappointments. Physiology & Behavior 135: 55-71
14 Hitachi (2006) World’s smallest and thinnest 0.15 x 0.15 mm, 7.5µm thick RFID IC chip. In Hitachi
15 Moberg GP, Mench JA (2000) Biological Response to Stress: Implications for Animal Welfare. The Biology of Animal Stress: Basic Principles and Implications for Animal Welfare. Wallingford, United Kingdom: CABI Publishing.
16 NASA (2013) Rodent Habitat: Studying Animals in Space Aboard the International Space Station. In NASA Facts.
17 National Health and Medical Research Council (2008) Guidelines to promote the wellbeing of animals used for scientific purposes: the assessment and alleviation of pain and distress in research animals. Canberra, Australian Capital Territory: National Health and Medical Research Council.
18 Newberry RC (1995) International Society for Applied Ethology 1995 Environmental enrichment: Increasing the biological relevance of captive environments. Applied Animal Behaviour Science 44: 229-243
19 Olsson IAS, Dahlborn K (2002) Improving housing conditions for laboratory mice: a review of ‘environmental enrichment’. Laboratory Animals 36: 243-270
20 Stauffacher M (1992) [Legitimate animal husbandry of domestic rabbits: new concepts for the breeding and raising of laboratory and meat rabbits]. Dtsch Tierarztl Wochenschr 99: 9-15
21 Vessel EA, Russo S (2015) Effects of reduced sensory stimulation and assessment of countermeasures for sensory stimulation augmentation. In NASA
22 Videos, Rodent Research 1 Payload Project Data Collection, ALSDA-S001-010. NASA Ames Life Sciences Data Archive. Ames Research Center, Moffett Field, CA.
23 Wahlsten, D., Metten, P., Phillips, T. J., Boehm, S. L. II, Burkhart-Kasch, S., Dorow, S., et al. (2003). Different data from different labs: lessons from studies of gene–environment interaction. J. Neurobiol. 54, 283–311. doi: 10.1002/neu.10173