ANTITUMOR ACTIVITY of EXTRACTS of Caulerpa taxifolia in the SARCOMA 180 TUMOR TREATMENT


ANTITUMOR ACTIVITY of EXTRACTS of Caulerpa taxifolia in the SARCOMA 180 TUMOR TREATMENT


Evandro Valentim da Silva1,2, Livia Nara Eugênio Pereira², Gabriela Cavalcante da Silva²; José Ferreira Silva Neto3, George Chaves Jimenez3, Fálba Bernadete Ramos dos Anjos1, Ivone Antonia de Souza2

1Department of Hstology and Embryology Universidad Federal of Pernambuco, Brazil; 2Department of Antibiotics Universidad Federal of Pernambuco, Brazil; 3Fisiology and Pharmacology Animal of Universidad Federal Rural of Pernambuco, Brazil;


Cancer is a disease characterized by the multiplication and spread out of control in the form of anomalous cells. A normal cell becomes cancerous cells as a result of one or more mutations of DNA. Marine algae are a rich source of bioactive compounds, some of which are precursors of pharmacological tools and potentially useful substances for the development of new drugs. The present study aims to evaluate the antitumor activity of Caulerpa taxifolia front of Sarcoma 180 in albino mice (Mus musculus). The transplanted animals with sarcoma 180 (n = 24), were divided into four groups (n = 6) treated with two extracts: the MeOH extract (T1) and from hydroalcoholic C. taxifolia (T2) at a dose of 50 mg/kg ip. The control group (S1) received saline for the same route of administration. The default group (S2) received the reference drug to the tumor lineage. The data revealed that the S3 and S4 group responded to treatment with reduction of 63.6 and 42, 0 % respectively, as compared to EN/PA, when compared with the control group. The activities of extracts were higher than those of the reference drug for the Sarcoma 180.


Keywords:phytotherapy, bioassay, bioactivity.


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How to cite this article:
Evandro Valentim da Silva, Livia Nara Eugênio Pereira, Gabriela Cavalcante da Silva; José Ferreira Silva Neto, George Chaves Jimenez, Fálba Bernadete Ramos dos Anjos, Ivone Antonia de Souza. ANTITUMOR ACTIVITY of EXTRACTS of Caulerpa taxifolia in the SARCOMA 180 TUMOR TREATMENT. Journal of Herbal Medicine Research, 2019,4:29. DOI: 10.28933/jhmr-2019-05-1005


References:

1. Goodman LS, Gilman AG. As bases farmacológicas da terapêutica. edited by Guanabara, Rio de Janeiro, RJ: McGrawHill, 2012,pp.85-123.
2. INCA – Instituto Nacional de Cancer, Rio de Janeiro, 2012, 2ª edição revista e atualizada. Disponível em:<http://bvsms.saude.gov.br/bvs/publicacoes/ inca/ABC_ do cancer_2ed.pdf.˃. Acesso em: 10 de maio de 2014.
3. INCA. Fisiopatologia do câncer. Disponível em: <http://www.inca.gov.br/ enfermagem/docs/cap2.pdf.˃ .Acesso em: 16 de junho de 2014.
4. Silva AER, Fiori ATM, Matsumoto C, Cruz A, Silva NMO, Bernardes ACA, Carvalho RP, Mazzola PG. Levantamento bibliográfico de antineoplásicos padronizados no Hospital da Mulher – Prof. Dr. José Aristodemo Pinotti (CAISM) UNICAMP In: Congresso dos Profissionais das Universidades de São Paulo, São Paulo: USP, Unicamp e Unesp, 2011.
5. Oliveira JS, Costa-Lotufo LV, Bezerra DP, Alencar NM, Marinho-Filho JD, Figueiredo IS, Moraes MO, Pessoa C, Alves AP, Ramos MV. In vivo growth inhibition of Sarcoma 180 by latex proteins from Calotropis procera. Naunyn Schmiedeberg’s Archives of Pharmacology. 2010; 382(2):139-49.
6. Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics. CA Cancer J. Clin.2007; 57(1):39-43.
7. Guerra MR, Gallo CVM, Mendonça G. Risco de câncer no Brasil: tendências e estudos epidemiológicos mais recentes. Revista Brasileira de Cancerologia.2005; 51(3):227-34.
8. Santos 2011
9. Natali ALC. Ação inotropica positiva do extrato metanolico de Bryopsis pennata (CHLOROPHYTA CAULERPALES). Dissertação (Metrado em Biociencia) Universidade de São Paulo. 2007.
10. Hay ME, Fenical W. Marine plant-herbivore interactions. The ecology of Chemical defense. Ecol. Syst, 1988; 19(1):111-45.
11. Solè-Cava AM, Kelecom A. Dialogo quimico dos mares, Ciência Hoje. 1988; 8(46):18-29.
12. Matos FJA, Oliveira F. Lippia sidoides Cham. Rev. Bras. Farmacognosia. 1998;79(1):84-87.
13. Di Stasi LC: Plantas medicinais: arte e ciência. Edited by Unesp. São Paulo, 1996,p. 129-56.
14. Geran RI, Greenberg NH, Mcdonald MM, Schumacher AM, Abbot BJ. Protocols for screening chemical agents and natural products against animal tumors and other biological systems. Cancer Chemoth.1972; 33(1):1–103.
15. Geran RI, Greenberg NH, Mcdonald MM, Schumacher AM, Abbot BJ. Protocols for screening chemical agents and natural products against animal tumors and other biological systems. Cancer Chemoth.1972; 33(1):1–103.
16. Robbins SL, Angell M, Kumar V. Patologia básica, Editora da Universidade de São Paulo.1984 Nov; 16(1):577-625.
17. Morettin LG. Estatística Básica: Probabilidade e Inferência. São Paulo:Pearson Prentice Hall.2010; 1(1): pp1-376.
18. Bezerra D P, Castro FO, Alves AP, Pessoa AC, Moraes MO, Silveira ER, Lima, MA, Elmiro FJ, Alencar NM, Mesquita RO, Lima MW, Costa-Lotufo LV. In vitro and in vivo antitumor effect of 5-FU combined with piplartine and piperine. Journal of Applied Toxicology. 2008; 28(2):156-63.
19. Bezerra DP, Marinho-Filho, FD, Alves AP, Pessoa C, Moraes MO, Pessoa OD, Torres MC, Torres MC, Silveira ER, VIANA FA, Costa-Lotufo LV. Antitumor activity of the essential oil from the leaves of Croton regelianus and its component ascaridole. Chemistry & Biodiverity.2009; 6(8):1224-31.
20. Gonzaga ML, Bezerra DP, Alves AP. In vivo growth of Sarcoma 180 by analpha-(14)- glucan(16)- glucan-protein complex polyccharide obtainned from Agaricus blazei Murrill. J.Nat.Med. 2009; 63(1):32-40.
21. Lins KO, Bezerra DP, Alves AP, Alencar NM, Lima MW, Torres VM, Pessoa C, Moraes, MO, Costa-Lotufo LV. Antitumor properties of a sulfated polysaccharide from the red seaweed Champia feldmannii (Diaz-Pifferer). Jornal of Applied Toxicology.2009;29(1):20-6.
22. Magalhães HI, Ferreira PM, Moura ES, Torroes MR, Alves AP, Pesso OD, Costa-Lotufo LV, Moraes, MO, Pessoa C. In vitro and in vivo antiproliferative activity of Calotropis procera stem extracts. Anais da Academia Brasileira de Ciências. 2010; 82(2):407-16.
23. Oliveira-Júnior RJ. Análises citogenéticas e expressão da telomerase em Sarcoma 180. Dissertação (Mestrado em Genética e Bioquímica) – Universidade Federal de Uberlândia, MG. 2008.
24. Moura CA, Silva EV, Cavalcanti KPS, Anjos FBR, Jimenez GC, Oliveira SF, Souza IA. Perfil Fitoquímico da Macroalgas Marinha Caulerpa taxifolia (VAHL) C.AGARDH, 1817 (caulerpaceae) Congresso Brasileiro de Oceanografia, Rio de Janeiro, Nov. 2012.
25. Robbins SL, Cotran RS. Patologia: Bases – Patologicas das doenças, ed.Elsevier,Rio de Janeiro, 2000, 7:1592.
26. Aguilar-Santos G, Chem J, SOC C. Chemical studies on three species of marine algal genus Caulerpa. In. Froedenthal, H.D. (ed.) Drugs from the sea. Marine Technology Society.1970; 84(2): 173-76.
27. Maiti BC, Thamson RH, Mahendran M. The structure of caulerpina, a pigment from Caulerpa algae. J. Chem. 1978 May; 34(5):126-27.