Journal of Herbal Medicine Research


Evaluation of Antibacterial Activity of Shigru Patra Churna

Research Article of Journal of Herbal Medicine Research Evaluation of Antibacterial Activity of Shigru Patra Churna Dr. Abhijeet D. Kumbhar1*, Dr. Vamsikrishna G. K.1, Dr. Surekha Khot2. 1*P. G. Scholar; 1 Professor & HOD; 2Associate Professor; Department of Post Graduate studies in Dravyaguna, Shri Shivayogeeshwar Rural Ayurvedic Medical College & Hospital, Inchal, Tahsil Soundatti, Dist. Belgavi. Background: Shigru (Moringa Oleifera Lam.) is a well known drug in Ayurveda used for its Krimighna activity (ability to kill the pathogens). Acharya Charaka had mentioned Shigru in Krimighna Mahakashaya1. Nighantus had specifically mentioned Krimighna activity of Shigru Patra viz. Kaiyadeva Nighantu2, Raj Nighantu3 and Shaligram4 Nighantu. Therefore Patra churna (powder of leaves) is selected for evaluation of anti bacterial activity on the strains which affects a large number of population. Methods : Shigru Patra churna at different concentrations viz. 5µl, 10µl, 25µl, 50µl and 75µl were tested for anti bacterial activity by Disc Diffusion method for 2 strains of Gram positive and 2 strains of Gram negative bacteria each, with DMSo (Dimethyl Sulphoxide) a neutral solvent. Zone of Inhibition was calculated. Result : Shigru Patra inhibits growth of Staphylococcus aureus, Pseudomonas auringinosa and Escheria coli at higher concentrations of 50µl and 75µl and is resistant to Streptococcus mutans at all concentrations. Zone of inhibition was 13mm for Staphylococcus aureus, 12mm for Pseudomonas auringinosa and 15mm for Escheria coli and activity index were 0.86, 0.40 and 0.50 respectively. Conclusion : Shigru Patra possess good anti bacterial activity against Staphylococcus aureus, Pseudomonas auringinosa and Escheria coli. Keywords:  Shigru, Moringa oleifera Lam, Zone of Inhibition, Anti bacterial, Activity Index, Bacteria ...

Alterations in the Glutamate metabolism and Aminotransferases (AAT, ALAT) during PTZ induced Epilepsy: Protective role of Bacopa monnieri

Research Article of Journal of Herbal Medicine Research Alterations in the Glutamate metabolism and Aminotransferases (AAT, ALAT) during PTZ - induced Epilepsy: Protective role of Bacopa monnieri E. Komali, Ch. Venkataramaiah and W. Rajendra* Division of Molecular Biology, Department of Zoology, Sri Venkateswara University- Tirupati Epilepsy, a common chronic neurological disorder characterized by repeated, spontaneous seizures, also known as seizure disorder. Seizure related neuronal injury has been assumed to be mediated by glutamate, the excitatory amino acid, in the central nervous system that causes a sudden imbalance between the inhibitory and excitatory signals in the brain with glutamate, γ-aminobutyric acid (GABA), noradrenaline, serotonin, and dopamine. Since long term usage of antiepileptic drugs cause high incidence of pharmacoresistence and untoward side effects, attention has been paid in recent years to screen bioactive compounds from natural medicinal plants for treatment of several neurological disorders including Epilepsy. Keeping in view of relative importance of natural medicinal plants, the present study is mainly focused to characterize the anti-convulsant effect of Bacopa monnieri (BM), an Indian herb which is being extensively used in Ayurvedic treatments related to neurological complications. The present study is designed to assess the neurotoxicity of Pentylene tetrazole (PTZ), an epileptic compounds, on the Glutamate metabolism and Amino transferases in different brain regions (Cerebral cortex, Cerebellum, Pons medulla and Hippocampus) of rat and to explore the possible antiepileptic effect of different extracts (Ethanol, n-Hexane, Chloroform, Ethyl acetate, n-Butanol and Aqueous extracts) of BM in comparison with Diazepam (DZ) (Reference control).  The activities of glutamate dehydrogenase (GDH), glutamine synthetase (GS) and glutamine content were decreased in different regions of brain during PTZ induced epilepsy which were increased in epileptic rats pretreated with different extracts of Bacopa monnieri except EAE and AE. Glutaminase activity was increased in PTZ induced epilepsy and decreased on pretreatment with ...

Microwave assisted Subcritical water extraction of Berberine hydrochloride from the roots of Berberis Aristata using Harmony search algorithm

Research Article of Journal of Herbal Medicine Research Microwave assisted Subcritical water extraction of Berberine hydrochloride from the roots of Berberis Aristata using Harmony search algorithm Hemanth Kumar Manikyam1 , C.Ramesh2 , Krishna Mohan Poluri3, Assif Assad4 1. Department of chemistry, North East Frontier Technical University , Arunachal Pradesh, India 2. School of pharmaceutical Management, IIHMR University, Jaipur, Rajasthan India. 3. Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, India. 4. Department of Mathematics, Indian Institute of Technology Roorkee, Roorkee, India. The aim of present study is to optimize the conditions of Berberine extraction from roots of Berberis Aristata by Microwave assisted subcritical water extraction (MASCW).MASCW method of extraction had shown reproducibility in respect to time, solvent usage, yield and extraction repeatability. Isoquinone Berberine, is one of the wide spread representatives belonging to family of protoberberine alkaloids abundantly present in roots and stem parts of Indian barberry. The subcritical factors like time, solvent/meal ratio, extraction repeatability, size of particles and temperature were investigated and were in accordance with experimental data and predicted data. Harmony search Algorithm (HSA) was used to study the effect of five subcritical parameters on the yield of Berberine .The extraction of berberine from roots of Berberis aristata was carried at 110-1700C using MASCW method using different variations of five subcritical parameters. The results show that all five factors (Time, Temperature, size of particles, repeatability of extraction and sample/liquid Ratio) have statistically significant effects on the berberine concentration. The results had suggested that experimental data concentration, 223.82 µg/ml and predicted data concentration, 214.854 µg/ml of berberine are in significant correlation at subcritical parameters like temperature 1700C, particle size of 0.65 mm, time of 70 mins, solvent/meal ratio of 12 and at maximum three repetitions. Thus the extracted berberine was precipitated as berberine hydrochloride by acid and further ...

Effects of Cinnamon on Blood Glucose Level and Lipid Profile in Syrian Type 2 Diabetes Patients

Research Article of Journal of Herbal Medicine Research Effects of Cinnamon on Blood Glucose Level and Lipid Profile in Syrian Type 2 Diabetes Patients Prof. Dr. Maher ALMOKDAD Department of Medical Biochemistry, Faculty of Medicine, Gaziantep University Gaziantep, Turkey. Mail address: Üniversite Bulvarı 27310 Şehitkamil, Gaziantep, Turkey. Diabetes mellitus (DM) is one of the most common metabolic disorders that causes micro- and macro-vascular complication. The aim of this study was to evaluate The effects of cinnamon on fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), and low density lipoprotein (LDL) in Syrian individuals with type 2 diabetes mellitus (T2DM). A total of 90 patients with type 2 diabetes (T2D), were randomized into two groups: one for placebo and one for treatment with cinnamon powder (Cinnamomum cassia), in daily amounts of 2 grams.  We measured the patients’ blood glucose and lipid levels under fasting conditions at the beginning of the study, and again at 30 days, the end of treatment. The mean value of FBG level on the starting day before cinnamon intake was found to be 176.8 ± 9.6 mg/dl, and the mean values for lipids were TG 183.5 ± 15.5 mg/dl, TC 209.4 ± 7.8 mg/dl and LDL 119.4 ± 5.8 mg/dl. When diabetic patients were treated with the dose of 2 g cinnamon for 30 days, their mean FBG level dropped to 147.4 ± 8.9 mg/dl, TG 135.7 ± 9.6 mg/dl, TC 149.3 ± 8.6 mg/dl and LDL to 74 ± 6.2 mg/dl. No significant changes were noted in the placebo groups.  The results of this study indicate that intake of 2 grams of cinnamon per day reduces serum glucose, TG, TC, and LDL and thus reducing the risk of diabetic complications. Keywords:  type 2 diabetes mellitus; fasting blood glucose; lipids;  cinnamon ...

Editor-in-chief: 

Dr. Juei-Tang Cheng 
 Chair-Professor, Institute of Medical Research, Chang Jung Christian University, Taiwan.

Editors

Dr.  George Perry
Dean and Professor of Biology and Chemistry and Semmes Foundation Distinguished University Chair in Neurobiology, College of Sciences, University of Texas at San Antonio, USA.

Dr. Abimbola Farinde
Professor, Columbia Southern University, Orange Beach, AL, USA.

Dr. Gianni Sacchetti 
Professor, Department of Life Sciences and Biotechnology, Corso Ercole I d’Este 32, 44121 Ferrara, Italy.

Dr. Pongsak Rattanachaikunsopon
Professor, Department of Biological Science, Faculty of Science, Ubon Ratchathani University, Ubon Ratchathani 34190, Thailand.

Dr. Atanas Pavlov
Professor, Department Industrial Microbiology, Laboratory of Applied Biotechnologies, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Bulgaria.

Dr. Parveen Bansal
Joint Director, University Centre of Excellence in Research, Baba Farid University of Health Sciences, Faridkot-151203 (Punjab), India.

Dr. Peter A. Akah
Professor, Department of Pharmacology and Toxicology, University of Nigeria, Nsukka, Nigeria.

Dr. Petropoulos Spyridon
Department of Agriculture, Crop Production and Rural Environment, School of Agricultural Sciences, University of Thessaly, Magnissia, Greece.

Dr.Rabin Chandra Paramanik
AL-Falah Group of Institutions, behind kalya Gate, Ramanagara District, Magadi - 562120, Karnataka, India.

Dr. Snehangsu Sinha
College of Veterinary Science, AAU, Guwahati, Assam

Dr. Bajpayee Kaptain Kishor
Assistant Professor &HOD in the Botany Department, DR.RML P.G. COLLEGE (C.S.J.M. UNIVERSITY), HARDOI 241001 INDIA.

Dr. Sidharth Mehan
Associate Professor, Department Of Pharmacology, Rajendra Institute Of Technology & Sciences (Rits), Doping Control Officer (Nada), Ministory Of Youth Affairs And Sports, Government Of India.

Dr. Manisha H.Vite.
Associate Professor, Shivajirao Jondhle college of pharmacy, Asangaon, Mumbai.

Dr. Mayuri C. Rathod

Assistant Professor, Biotechnology Department, C.R.C. Building, Veer  Narmad  South Gujarat university,

Dr Ranjeet Satyawan Sawant
Assistant Professor, Dept. of Rasashastra & BK, KGMP Ayurvedic Mahavidyalaya, Charni Road, Mumbai.

Dr Jiban Shrestha
Scientist (Plant Breeding & Genetics), Nepal Agricultural Research Council, National Maize Research Program, Rampur, Chitwan, Nepal

Dr. K.S. Kanwal
Scientist-C, G.B. Pant National Institute of Himalayan Environment and Sustainable Development, North East Unit, Vivek Vihar, Itanagar-791113, Arunachal Pradesh, India

Dr. Swapnil Sabgonda Patil
Assistant Professor of Dept. of Rognidan Avum Vikrutividnyan and Working as a Pathologist in Dhanwantari Hospital, Ashta, Dist. Sangli.

Dr. Rozbeh Farhoudi
Head, Department of Agronomy and Plant Breeding, College of Agriculture, Islamic Azad University, Shoshtar Branch, Shoshtar, Iran.

Dr. Ayub Khan
Chairman & Professor, Department of Agricultural Sciences, University of Haripur, Khyber Pakhtunkhwa, Pakistan.

Dr. Muhammad Hamayun 
Associate Professor & Chairman, Department of Botany, Abdul Wali Khan University Mardan (AWKUM), Khyber Pakhtunkhwa, Pakistan.

Dr. Amit R. Nampalliwar
Assistant Professor, Smt. K.G. Mittal Ayurved Medical College & Hospital, N.S. Road, Charni Road Station(West), MUMBAI-400002, India.

Dr. Fahmy Abd El-Rahman Sadek Hassan

Professor of Medicinal & Ornamental plants, Faculty of Agriculture, Tanta University, Egypt.

Dr. Kaptain Kishor Bajpayee
Assistant Professor & Head Deptt. of botany, Dr. RML degree college (C.S.J.M. University), Hardoi up241001, india.

Dr. Majid Sharifi-Rad
Department of Range and Watershed Management, Faculty of Natural Resources, University of Zabol,  Iran.

Dr. Devendra Kumar Patel
Assistant Professor, Rural Technology Department, Guru Ghasidas Vishwavidyalaya, (A Central University), Bilaspur (Chhattisgarh), India.

Dr.  Shyamapada Mandal
Associate Professor and Head, Department of Zoology, Laboratory of Microbiology and Experimental Medicine, University of Gour Banga, Malda-732 103, India

Dr. Abhishek J. Joshi
Chair of Ayurveda, Fakultas Ayurweda, Universitas Hindu Indonesia(UNHI), Denpasar, Bali, Republic of Indonesia.

Dr.  Datta Asaram Dhale
Assistant Professor, Post-Graduate Department of Botany, S.S.V.P.S.’S, L.K. Dr. P. R. Ghogrey Science College, Dhule, Maharashtra, India.

Dr. Ravi Shankar khatri
Assistant professor, Dep’t of Kaumarbhritya, A & U Tibbia College and hospital, karol bagh, India.

Dr. Shahin Gavanji
Chairman of “WAMS National Council of Iran at World Academy of Medical Sciences (WAMS), Chairman WAMS Oncology Research Group of Iran, Young Researchers and Elite Club, Khorasgan Branch, Islamic Azad University, Khorasgan, Isfahan, Iran, Department of Biotechnology, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan, Iran.

Dr. Munesh Kumar
Assistant Professor, Department of Forestry, HNB Garhwal University, Srinagar Garhwal, Uttarakhand-249161, India

Dr. Shicheng Guo
Department of Bioengineering, The University of California, San Diego, 9500 Gilman Drive MC 0412, La Jolla, CA, USA.

Dr. Mario Bernardo-Filho
Professor Titular, Universidade do Estado do Rio de Janeiro

Dr. Parichat Phumkhachorn
Assistant Professor, Faculty of Science, Ubon Ratchathani University

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1. Vikas Gupta, Parveen Bansal, Junaid Niazi, Kamlesh Kohli, Pankaj Ghaiye. Anti-anxiety Activity of Citrus paradisi var. duncan Extracts in Swiss Albino Mice-A Preclinical Study. Journal of Herbal Medicine Research, 2016; 1(1): 0001-0006.

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