Progress in the application of LOV2 domain in protein interaction


Progress in the application of LOV2 domain in protein interaction


Xiao Shao

College of Medical , China Three Gorges University, Yichang, 443002, China.


Journal of Pharmaceutical Research and Reviews

Protein-protein interactions (PPIs) and protein complexes formed by interactions are the main accomplishers of various functions of cells. As an important component of biological networks, protein interaction plays an important role in determining life processes such as signal transduction in cells. Although the experimental methods for studying protein interactions are endless, there are still many shortcomings and gaps in the research on the interaction of precisely regulated protein molecules. LOV (Light Oxygen Voltage) is a light-sensitive protein domain originally discovered in the photo of plants for receiving blue light stimulation, transmitting signals, and causing a series of reactions in plants. The LOV domain belongs to a member of the PAS (Per-Arnt-Sim) superfamily and contains two subunits, LOV1 and LOV2. LOV2 is thought to cause a conformational change after receiving light stimulation, primarily responsible for activating the kinase domain. It plays an important role in intracellular signal transduction. In view of the light control and sensitivity of LOV2, which can be used as a research tool in protein interaction processes, the mechanism of action and structural advantages of signal transduction in LOV2 domain in protein interactions are reviewed.


Keywords: Protein interaction; LOV2 domain; Optogenetics; Light-sensitive protein; Photon

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How to cite this article:
Xiao Shao. Progress in the applicat-ion of LOV2 domain in protein inter-action. Journal of Pharmaceutical Research and Reviews, 2019; 3:17. DOI:10.28933/jprr-2019-05-1806


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