Editorial Board of International Journal of Neuroscience Research
Dr. Abdelrahman Y. Fouda
Vascular Biology Center, R.B. Caldwell lab, Augusta University
Biography & Research Interest
Welcome Dr. Abdelrahman Y. Fouda to Join the Editorial Board of International Journal of Neuroscience Research.
Since I started my PhD program in 2011, I became interested in the pathophysiology of central nervous system (CNS) ischemia reperfusion (IR) injury. I joined Dr. Fagan’s stroke lab in 2011. During my 4 years as a graduate student, and 1 year as a postdoc, I have successfully completed and published several research papers and reviews on neurovascular protection through angiotensin system modulation. Overall, I have generated 5 first author research papers (4 published and 1 in preparation). I have also co-authored 4 manuscripts and 6 review articles (1 as first author). The most relevant articles to the current project are:
1. Alhusban A*, Fouda AY* (*equal contribution), Pillai B, Ishrat T, Soliman S, and Fagan SC. Compound 21 is proangiogenic in the brain and results in sustained recovery after ischemic stroke. Journal of Hypertension 2015 Jan;33(1):170-80.
2. Fouda AY*, Alhusban A* (*equal contribution), Ishrat T, Pillai B, Eldahshan W, Waller JL, Ergul A, Fagan SC. Brain-derived neurotrophic factor knockdown blocks the angiogenic and protective effects of angiotensin modulation after experimental stroke. Molecular Neurobiology 2017 Jan;54(1):661- 670.
3. Fouda AY, Artham S, El-Remessy A and Fagan SC. Renin angiotensin system as a potential therapeutic target in stroke and retinopathy: Experimental and clinical evidence. Clinical Science 2016 Feb;130(4):221-38.
4. Fouda AY, Pillai B, Dhandapani K, Ergul A, Fagan SC. Role of interleukin 10 in compound 21 mediated functional recovery after stroke. European Journal of Pharmacology (Accepted Feb 2017).
Working in the stroke lab under Dr. Fagan’s mentorship provided me with the necessary experience and skills to move on to my second postdoc in Dr. Caldwell’s retinopathy lab. Dr. Caldwell is an internationally recognized leader in the retinopathy field with an outstanding record for training postdocs to become independent investigators. Dr. Caldwell’s lab is part of the Vascular Biology Center (VBC) at Augusta University (AU). Being part of the VBC, I receive extensive postdoc training that provides me with excellent background in different vascular biology disciplines through weekly seminars and journal clubs as well as meetings with the faculty. In addition, our lab is part of the Culver Vision Discovery Institute (VDI) that comprises a group of basic and clinical scientists at AU. The VDI has a monthly seminar series and an annual retreat, which further exposes me to various retinopathy research projects. Since, I joined the retinopathy lab in April 2016, Dr. Caldwell has provided me with full support to develop my own project. Benefiting from the established retinal IR injury model in lab, I decided to develop a project focusing on the role of macrophage in retinal IR in relation the enzyme arginase 1. Arginase has been extensively studied in our lab and it has a central role in macrophage polarization from the inflammatory M1 to the protective M2 phenotype. The proposed study will be a new research niche in the retinopathy lab. I have generated solid preliminary data that strongly support this fellowship. This project will expose me to new techniques and research tools in the retinopathy field through working with senior lab members and collaboration with other labs in the VDI and AU. Upon successful completion of this project, we will further elucidate the protective role of arginase 1 in retinal IR and pave the way for translating pegylated arginase (an investigational drug) to the clinical setting for different IR disorders. Based on my training experience, the research environment and collaborations, I believe I am capable of successfully completing the proposed project under Dr. Caldwell’s mentorship. Securing this AHA postdoctoral fellowship will provide me with a comprehensive postdoctoral training plan and will further hone my research skills. In addition, it will lay the foundation to apply for future grants to achieve my long-term career goal to become an independent investigator and establish my own research lab in the field of translational CNS IR injury.